Application of Humanized MHC Transgenic Mice in the Screening of HLA–Restricted T Cell Epitopes for Influenza Vaccines
The HLA-A2/DR1 and HLA-A11/DR1 transgenic mouse models can be used for the direct screening and validation of influenza virus T cell epitopes, which is crucial for designing T cell epitope vaccines against influenza viruses. Further, this method can be applied in epitope screening and vaccine designing before the spread of other emerging and sudden infectious diseases, thereby supporting epidemic control.
Authors
- Kai Yuan (ORCID: https://orcid.org/0000-0003-3692-1648)
- Xuelian Han
- Guangyu Zhao (ORCID: https://orcid.org/0000-0002-0925-5216)
- Tiantian Yang (ORCID: https://orcid.org/0009-0000-0499-336X)
- Qi Yin (ORCID: https://orcid.org/0000-0002-5844-7038)
- Yali Sun
- Min Li (ORCID: https://orcid.org/0000-0002-2776-679X)
- Keyu Sun (ORCID: https://orcid.org/0000-0002-9451-9019)
- Jiejie Zhang (ORCID: https://orcid.org/0009-0006-1419-0636)
- Yuwei Wei
- Yuan Wang (ORCID: https://orcid.org/0009-0000-5713-3830)
Institutions
- Anhui Medical University (CN)
- Academy of Military Medical Sciences (CN)
- Mudanjiang Medical University (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3390/vaccines13030331
- Citations
- 2
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- State Key Laboratory of Pathogen and Biosecurity
- National Key Research and Development Program of China