Costunolide inhibits the progression of TPA-induced cell transformation and DMBA/TPA-induced skin carcinogenesis by regulation of AKT-mediated signaling
These results demonstrate that COS inhibits TPA-induced cellular transformation and skin carcinogenesis both in vitro and in vivo through the AKT signaling pathway. Our findings suggest the potential of COS as a chemopreventive agent for skin carcinogenesis, highlighting its significance for further investigation in cancer prevention and therapy.
Authors
- Young-Gwon Kim (ORCID: https://orcid.org/0009-0000-8085-7319)
- Mee‐Hyun Lee (ORCID: https://orcid.org/0000-0002-1216-0218)
- Sun‐Young Hwang (ORCID: https://orcid.org/0000-0002-0603-5381)
- Je–Ho Lee (ORCID: https://orcid.org/0000-0002-9035-2602)
- Kwanhwan Wi
- Geul Bang (ORCID: https://orcid.org/0000-0002-8762-9877)
- Soong-In Lee (ORCID: https://orcid.org/0000-0002-5354-1746)
- Cheol‐Jung Lee (ORCID: https://orcid.org/0000-0002-0322-2018)
Institutions
- Dongshin University (KR)
- Korea Basic Science Institute (KR)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12935-025-03742-w
- Citations
- 4
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Ministry of Science and ICT, South Korea