Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury
We have identified a novel protective role of Sema7a during injury phases of APAP-ALI. Without peri-necrotic hepatocyte Sema7a expression and secretion, there is increased inflammation, time specific worsened hepatic necrosis and increased hepatic cell stress and death outside of the necrotic zone.
Authors
- Adriano G. Rossi (ORCID: https://orcid.org/0000-0003-3173-9521)
- Rhona Aird (ORCID: https://orcid.org/0000-0002-1014-8063)
- Stuart J. Forbes (ORCID: https://orcid.org/0000-0003-3715-2561)
- Benjamin J. Dwyer (ORCID: https://orcid.org/0000-0003-2527-5417)
- Lara Campana (ORCID: https://orcid.org/0000-0003-1805-4755)
- Luke Boulter (ORCID: https://orcid.org/0000-0002-7954-6705)
- Matthieu Vermeren (ORCID: https://orcid.org/0000-0003-3584-0387)
- Eilidh Livingstone (ORCID: https://orcid.org/0000-0002-3599-1567)
- Tak Yung Man (ORCID: https://orcid.org/0000-0002-8452-2417)
- Jennifer A. Cartwright (ORCID: https://orcid.org/0000-0003-1143-9011)
- Philip J. Starkey Lewis
Institutions
- MRC Centre for Regenerative Medicine (GB)
- Centre for Inflammation Research (GB)
- Institute of Genetics and Cancer (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12950-025-00429-x
- Citations
- 3
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Wellcome Trust
- Medical Research Council