Serendipitous pathway to naphtho[2,1-<i>b</i>]furan and its thioether enabled by triflic acid and thiol-mediated reaction
We have developed a selective method for 2-phenyl naphthofuran and thio-ether derivatives using hydroxy naphthofuranone and thiols in triflic acid. Product selectivity is controlled by altering the reagent equivalents. This broad-scope, acid-mediated strategy enables diverse functionalization, overcoming regioselectivity challenges and providing a valuable tool for medicinal chemistry and organic synthesis.
Authors
- Bhaskaran Shankar (ORCID: https://orcid.org/0000-0001-8234-3645)
- Subburethinam Ramesh
- Vijayakumar Hemamalini
Institutions
- SASTRA University (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00753d
- Citations
- 1
- Primary Topic
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.94