[Role of antibiotic delivery system targeting bacterial biofilm based on ε-poly- <i>L</i>-lysine and cyclodextrin in treatment of bone and joint infections].
The ε-PLL-CD antibiotic delivery system provides a treatment strategy for bone and joint infections with high clinical translational significance. By effectively enhancing antibiotic bioavailability, penetrating, and disrupting biofilms, it demonstrated significant anti-infection effects in animal models.
Authors
- Xianyou Zheng (ORCID: https://orcid.org/0000-0002-9770-5394)
- Junqing Lin (ORCID: https://orcid.org/0000-0003-0498-4847)
- Tiexin Liu
Institutions
- Shanghai Medical Information Center (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-15
- DOI
- https://doi.org/10.7507/1002-1892.202412031
- Primary Topic
- Biopolymer Synthesis and Applications
- Type
- article