Can aspartate aminotransferase and platelet distribution width-to-platelet ratio in the first trimester predict fetal macrosomia?: a retrospective case-control study

Higher aspartate aminotransferase and platelet distribution width-to-platelet ratio levels in the maternal blood sample in the first trimester indicate an unbalanced inflammatory process causing fetal macrosomia. The cutoff values for aspartate aminotransferase (>21 U/L) at 94% specificity and for platelet distribution width-to-platelet ratio (>0.19) at 51% specificity can be used as markers for a screening test. However, randomized controlled trials combining body mass index and the parameters in the present study are needed in future studies.