Identification of metabolite biomarkers for pancreatic neuroendocrine tumours using a metabolomic approach
This study highlights the distinct plasma metabolic signatures of pNETs, including the critical role of FAO and elevated glutamate levels in metastasis, supporting the energy and biosynthetic needs of rapidly proliferating tumour cells. Mapping of these dysregulated metabolites may facilitate the identification of new therapeutic targets for pNETs management.
Authors
- Anne‐Frédérique Dessein (ORCID: https://orcid.org/0000-0003-1713-0402)
- François Pattou (ORCID: https://orcid.org/0000-0001-8388-3766)
- Isabelle Van Seuningen (ORCID: https://orcid.org/0000-0002-3131-2694)
- Catherine Cardot-Bauters
- Benjamin Chevalier (ORCID: https://orcid.org/0000-0001-6449-3148)
- Nicolas Jonckheere (ORCID: https://orcid.org/0000-0002-0496-0661)
- Amandine Descat (ORCID: https://orcid.org/0000-0002-5981-4995)
- J Vandael
- Arnaud Jannin (ORCID: https://orcid.org/0000-0002-6031-4816)
- Stéphanie Espiard (ORCID: https://orcid.org/0000-0002-9584-4294)
- Medhi El Amrani
- Marie‐Christine Vantyghem (ORCID: https://orcid.org/0000-0002-9369-0463)
- Benjamin Marsac
- Sophie Dabo‐Niang (ORCID: https://orcid.org/0000-0002-4000-6752)
- Christine Do Cao (ORCID: https://orcid.org/0000-0002-1617-0149)
- Camille Marciniak (ORCID: https://orcid.org/0000-0003-2599-709X)
- Lucie Coppin
- Robert Caiazzo (ORCID: https://orcid.org/0000-0001-7403-7330)
- Jean François Goossens
- Sophie Dominguez
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Catholique de Lille (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille’s Cardiology Hospital (FR)
- Normandie Université (FR)
- Centre Oscar Lambret (FR)
- Laboratoire Paul Painlevé (FR)
- European Genomic Institute for Diabetes (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1093/ejendo/lvaf055
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35