Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease
Clinical data were used to identify subtypes of patients with Alzheimer's disease (AD) in the National Alzheimer's Coordinating Center dataset. Three problem history subtypes were found: minimal, substance use, and cardiovascular. The mean change in Clinical Dementia Rating Sum of Boxes (CDR-SB) was assessed over a 2 year follow-up. The cardiovascular subtype was associated with the worst cognitive decline. The magnitude of change in CDR-SB was similar to recent AD clinical trials.
Authors
- Diego R. Mazzotti (ORCID: https://orcid.org/0000-0003-3924-9199)
- Mihaela E. Sardiu (ORCID: https://orcid.org/0000-0002-3987-7569)
- Russell Howard Swerdlow (ORCID: https://orcid.org/0000-0003-2948-7230)
- Robyn A. Honea (ORCID: https://orcid.org/0000-0002-4661-2024)
- Clayton O. Mansel (ORCID: https://orcid.org/0000-0002-0135-7576)
- Ryan Townley (ORCID: https://orcid.org/0000-0002-3566-3969)
- Olivia J. Veatch (ORCID: https://orcid.org/0000-0002-5509-7749)
Institutions
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70017
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Association for Colitis and Crohn's Disease
- National Institutes of Health
- National Institute on Aging