A new sesterterpenoid with <i>β</i> -glucuronidase inhibitory activity from the <i>Cordyceps</i> -colonising fungus <i>Aspergillus versicolour</i> ZJUTE2
A new sesterterpenoid versicolorin A (<b>1</b>) and five known compounds <b>2</b>-<b>6</b> were isolated from a <i>Cordyceps</i>-colonising fungus <i>Aspergillus versicolour</i> ZJUTE2 cultured on soybean meal. The planar structure of <b>1</b> was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of <b>1</b> was established by NOESY experiment, quantum chemical calculation of <sup>13</sup>C NMR combined with DP4+ probability analysis, and comparison of the optical rotations. Compound <b>1</b> exhibited comparable <i>in vitro β</i>-glucuronidase inhibitory activity (IC<sub>50</sub> = 49.82 ± 1.21 µM) with D-saccharicacid 1,4-lactone (IC<sub>50</sub> = 57.35 ± 0.78 µM).
Authors
- You‐Min Ying (ORCID: https://orcid.org/0000-0002-2231-5068)
- Sha Xu (ORCID: https://orcid.org/0000-0001-8987-4940)
- Jing Tang (ORCID: https://orcid.org/0000-0001-9143-2674)
- Yixian Qiu (ORCID: https://orcid.org/0009-0008-6880-4394)
- Cui‐Ping Tong
- Yun Zhang (ORCID: https://orcid.org/0009-0008-2921-8739)
- Wei Mao
- Jiayue Ni
- Yuhao Lin (ORCID: https://orcid.org/0009-0006-0745-9190)
Institutions
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1080/14786419.2025.2481477
- Citations
- 2
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Natural Science Foundation of Zhejiang Province