Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8
The functional significance of Nav1.8 varies among different types of ventricular and conduction system cardiomyocytes. The reduction in I<sub>Na,L</sub> and APD, as well as suppression of early afterdepolarizations by Nav1.8 block in Purkinje fibers suggests Nav1.8 as a potential therapeutic target for bradycardia-dependent arrhythmias.
Authors
- Charles Antzelevitch (ORCID: https://orcid.org/0000-0001-7349-1582)
- Guohua Fan (ORCID: https://orcid.org/0000-0003-2950-191X)
- Dan Hu (ORCID: https://orcid.org/0000-0002-0994-8434)
- Hong-Yi Duan
- Zhonghe Zhang
- Héctor Barajas-Martínez (ORCID: https://orcid.org/0000-0002-2704-3807)
- Hao Xia (ORCID: https://orcid.org/0000-0001-6172-2152)
- Hong Jiang (ORCID: https://orcid.org/0000-0003-2222-0816)
Institutions
- Thomas Jefferson University (US)
- Lankenau Institute for Medical Research (US)
- Wuhan University (CN)
- Lankenau Heart Institute (US)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fcvm.2025.1546803
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39