Causal relationships between schizophrenia and psoriasis: a two-sample Mendelian randomization study
Our MR study established a significant association between schizophrenia and psoriasis vulgaris, identifying tenseness, tiredness, and misery as potential mediators. Pathway and functional enrichment analyses indicated that oxidative stress in the HPA axis may represent a shared mechanism underlying schizophrenia and psoriasis.
Authors
- Ying Zhang (ORCID: https://orcid.org/0000-0001-8398-2481)
- Lusheng Miao (ORCID: https://orcid.org/0009-0008-1575-7678)
- Jin Hao
- Taosheng Miao
Institutions
- Guangzhou University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12888-025-06687-6
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00