Weibull-Type Incubation Period and Time of Exposure Using γ-Divergence

Accurately determining the exposure time to an infectious pathogen, together with the corresponding incubation period, is vital for identifying infection sources and implementing targeted public health interventions. However, real-world outbreak data often include outliers-namely, tertiary or subsequent infection cases not directly linked to the initial source-that complicate the estimation of exposure time. To address this challenge, we introduce a robust estimation framework based on a three-parameter Weibull distribution in which the location parameter naturally corresponds to the unknown exposure time. Our method employs a γ-divergence criterion-a robust generalization of the standard cross-entropy criterion-optimized via a tailored majorization-minimization (MM) algorithm designed to guarantee a monotonic decrease in the objective function despite the non-convexity typically present in robust formulations. Extensive Monte Carlo simulations demonstrate that our approach outperforms conventional estimation methods in terms of bias and mean squared error as well as in estimating the incubation period. Moreover, applications to real-world surveillance data on COVID-19 illustrate the practical advantages of the proposed method. These findings highlight the method's robustness and efficiency in scenarios where data contamination from secondary or tertiary infections is common, showing its potential value for early outbreak detection and rapid epidemiological response.

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Publication Details

Journal
Entropy
Published
2025-03-19
DOI
https://doi.org/10.3390/e27030321
Primary Topic
COVID-19 epidemiological studies
Type
article
Field-Weighted Citation Impact
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article

Weibull-Type Incubation Period and Time of Exposure Using γ-Divergence

Takayuki Kawashima, Daisuke Yoneoka, Akifumi Eguchi, Yuta Tanoue et al.
Entropy
COVID-19 epidemiological studies
article

Weibull-Type Incubation Period and Time of Exposure Using γ-Divergence

Takayuki Kawashima, Daisuke Yoneoka, Akifumi Eguchi, Yuta Tanoue, Shuhei Nomura
article en

Abstract

Accurately determining the exposure time to an infectious pathogen, together with the corresponding incubation period, is vital for identifying infection sources and implementing targeted public health interventions. However, real-world outbreak data often include outliers-namely, tertiary or subsequent infection cases not directly linked to the initial source-that complicate the estimation of exposure time. To address this challenge, we introduce a robust estimation framework based on a three-parameter Weibull distribution in which the location parameter naturally corresponds to the unknown exposure time. Our method employs a γ-divergence criterion-a robust generalization of the standard cross-entropy criterion-optimized via a tailored majorization-minimization (MM) algorithm designed to guarantee a monotonic decrease in the objective function despite the non-convexity typically present in robust formulations. Extensive Monte Carlo simulations demonstrate that our approach outperforms conventional estimation methods in terms of bias and mean squared error as well as in estimating the incubation period. Moreover, applications to real-world surveillance data on COVID-19 illustrate the practical advantages of the proposed method. These findings highlight the method's robustness and efficiency in scenarios where data contamination from secondary or tertiary infections is common, showing its potential value for early outbreak detection and rapid epidemiological response.

EntropyVol. 27(3)
Chiba University (JP), Keio University (JP), National Institute of Infectious Diseases (JP), Tokyo University of Marine Science and Technology (JP)
Good health and well-being
Openalex Percentile: Top 94%
COVID-19 epidemiological studies
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Weibull-Type Incubation Period and Time of Exposure Using γ-Divergence — Takayuki Kawashima, Daisuke Yoneoka, et al. · Entropy (2025) | TGRS Research Map | TGRS