Prophylaxis against <i>Pneumocystis jirovecii</i> pneumonia and toxoplasmosis with low-dose Trimethoprim-sulfamethoxazole (cotrimoxazole 20/100 mg) in heart transplant patients. The PAPTO-LOCO observational comparative study
This retrospective study suggests that a low-dose SXT Pneumocystis prophylaxis strategy might offer a more favourable safety/efficacy profile than standard-dose prophylaxis after heart transplantation. These results should be confirmed in an interventional trial. Caution remains for toxoplasmosis serology D+/R- profiles.
Authors
- Eva Désiré
- Sandrine Houzé (ORCID: https://orcid.org/0000-0001-9016-3847)
- Lara Zafrani
- Mickaël Lescroart (ORCID: https://orcid.org/0000-0002-0070-5356)
- Guillaume Coutance (ORCID: https://orcid.org/0000-0003-4939-2175)
- Pascal Leprince (ORCID: https://orcid.org/0000-0003-2870-8273)
- Arnaud Fekkar (ORCID: https://orcid.org/0000-0001-9954-075X)
- Alexandre Bleibtreu (ORCID: https://orcid.org/0000-0001-5145-4174)
- Dahlia Aggoun
- S. Varnous
- Constance Verdonk
Institutions
- Université Paris Cité (FR)
- Saint Louis University Hospital (US)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Bichat-Claude-Bernard (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1093/jac/dkaf087
- Citations
- 2
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71