Causal relationships between serum metabolites and coronary heart disease risk: a mendelian randomization study

MR analysis revealed 6 protective molecules, 9 hazardous metabolites associated with CHD. Many of these known metabolites are closely link to mitochondrial function, suggesting a critical role of mitochondria in CHD development. In particular, hexadecanedioate, an essential component for mitochondrial energy production, was inversely associated with CHD risk. This suggests that mitochondrial function, and specifically the role of hexadecanedioate, may be pivotal in the development and progression of CHD.