Study on the invitro synergistic susceptibility and biofilm inhibition mechanism of ceftazidime-avibactam combined with aztreonam against carbapenem-resistant Klebsiella pneumoniae
The combination of ATM and CZA shows a strong synergistic antibacterial effect against CRKP strains with various enzyme types, with particularly notable synergy in strains carrying the <i>blaKPC-2</i> resistance gene. Additionally, this combination significantly disrupts the cellular structure of CRKP and inhibits biofilm formation.
Authors
- Qingcao Li (ORCID: https://orcid.org/0000-0002-8769-8370)
- Xuedan Qiu
- Jian Zhou (ORCID: https://orcid.org/0000-0002-9464-8857)
- Fang Cui (ORCID: https://orcid.org/0000-0001-7534-0753)
- G.Q. Wang
- Qiaoping Wu (ORCID: https://orcid.org/0000-0002-8796-2952)
- Jianqiang Xu (ORCID: https://orcid.org/0000-0002-1289-5943)
- Jinyuan Chen (ORCID: https://orcid.org/0000-0003-1547-5511)
- Hui Zhang (ORCID: https://orcid.org/0009-0007-5278-6358)
Institutions
- Ningbo University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fmicb.2025.1542029
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18