IgE autoantibodies to nuclear antigens in patients with different connective tissue diseases: re-evaluation and novel findings
IgE anti-SSA/Ro-, -SSB/La-, -RNP-, and -dsDNA antibodies show a high frequency and specificity for the prevailing CTD. We confirmed an association of anti-dsDNA and anti-SSA/Ro52 antibodies with disease activity in SLE. In MCTD, there was an association of anti-Sm/RNP B and -RNP68 antibodies with pulmonary disorder.
Authors
- Kathrin Kramer
- Jörg Henes (ORCID: https://orcid.org/0000-0002-8385-6861)
- Ann‐Christin Pecher (ORCID: https://orcid.org/0000-0003-0201-0686)
- Reinhild Klein (ORCID: https://orcid.org/0000-0002-6111-3901)
Institutions
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1483815
- Citations
- 4
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Medizinischen Fakultät, Eberhard Karls Universität Tübingen