CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer
In aggregate, our findings unveil the circPVT1/miR-33a-5p/Myc/GLS1 axis as a pro-tumorigenic metabolic event sustaining breast cancer transformation with potential therapeutic implications.
Authors
- Alina Catalina Palcau
- Fulvia Pimpinelli (ORCID: https://orcid.org/0000-0002-8321-4455)
- Sabrina Strano (ORCID: https://orcid.org/0000-0002-6341-4230)
- Claudio Botti (ORCID: https://orcid.org/0000-0002-5814-6876)
- Federica Lo Sardo (ORCID: https://orcid.org/0000-0002-2912-079X)
- Valentina De Pascale (ORCID: https://orcid.org/0000-0003-1015-8867)
- Sara Donzelli (ORCID: https://orcid.org/0000-0002-8529-2895)
- Francesca R. Auciello (ORCID: https://orcid.org/0000-0001-5151-0789)
- Giovanni Blandino (ORCID: https://orcid.org/0000-0002-6970-2241)
- Valeria Canu (ORCID: https://orcid.org/0000-0001-9085-7320)
- Paola C. Muti (ORCID: https://orcid.org/0000-0003-0339-8520)
- Daniela Rutigliano
- Andrea Sacconi (ORCID: https://orcid.org/0000-0002-8276-0438)
- Mariacristina Valerio (ORCID: https://orcid.org/0000-0001-7740-9945)
- Claudio Pulito (ORCID: https://orcid.org/0000-0002-0921-6962)
- Luca Casadei (ORCID: https://orcid.org/0000-0002-6977-5010)
Institutions
- University of Milan (IT)
- San Gallicano Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Impact (CA)
- Sapienza University of Rome (IT)
- McMaster University (CA)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13046-025-03355-1
- Citations
- 12
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.67