Cyclin E1 overexpression triggers interferon signaling and is associated with antitumor immunity in breast cancer
Our data show that cyclin E1 overexpression associate with antitumor immunity through activation of innate inflammatory signaling and warrants investigation into amplification or overexpression of cyclin E1 in identifying patients with breast cancer eligible for immunotherapy.
Authors
- Rudolf S.N. Fehrmann (ORCID: https://orcid.org/0000-0002-7516-315X)
- Bert van der Vegt (ORCID: https://orcid.org/0000-0002-2613-1506)
- Mengting Chen (ORCID: https://orcid.org/0000-0001-6001-9270)
- Marcel A.T.M. van Vugt (ORCID: https://orcid.org/0000-0002-3202-4678)
- Mieke C. Zwager (ORCID: https://orcid.org/0000-0002-4470-7628)
- Shibo Yu (ORCID: https://orcid.org/0000-0001-5646-5710)
- Tineke van der Sluis
- Matthew Dekker (ORCID: https://orcid.org/0009-0003-9272-7302)
- Arkajyoti Bhattacharya (ORCID: https://orcid.org/0000-0003-1479-0739)
- Carolien P. Schröder
- Chantal Stappenbelt
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- The Netherlands Cancer Institute (NL)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-009239
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- China Scholarship Council