The interaction between a leflunomide-response methylation site (cg17330251) and variant (rs705379) on response to leflunomide in patients with rheumatoid arthritis
The RA patients with SNP-rs705379-CC, the low methylation level of <i>PON1</i>-cg17330251 and more SIRI would be susceptible of response to LEF and more suitable to choose LEF treatment.
Authors
- Lingyu Fu (ORCID: https://orcid.org/0000-0003-3400-2509)
- Haina Liu
- Bingbing Dai (ORCID: https://orcid.org/0000-0002-2100-6415)
- Ruobing Liao
- Lei Jin (ORCID: https://orcid.org/0000-0001-6836-1142)
- Meng Chen (ORCID: https://orcid.org/0000-0002-2449-5904)
- Yulan Chen (ORCID: https://orcid.org/0000-0001-9726-8908)
- Xinliang Feng (ORCID: https://orcid.org/0000-0003-3885-2703)
- Feng Zhao
- Yuxin Yao (ORCID: https://orcid.org/0000-0002-7356-5542)
- Bingjia Qu
- Ying Song
- Junyi Zhao
- Qiao Wang (ORCID: https://orcid.org/0000-0002-6570-8160)
Institutions
- Sheng Jing Hospital (CN)
- Dalian Municipal Central Hospital (CN)
- First Hospital of China Medical University (CN)
- Jinzhou Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fphar.2025.1499723
- Citations
- 1
- Primary Topic
- Paraoxonase enzyme and polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 1.32