Hexokinase2-engineered T cells display increased anti-tumor function
HK2 overexpression improves T-cell metabolic fitness and functionality in hostile TMEs, offering a promising foundation for the development of next-generation immunotherapies targeting T-cell metabolism.
Authors
- Raphaëlle Toledano Zur
- Maria Radman (ORCID: https://orcid.org/0000-0003-4944-5222)
- Cyrille J. Cohen (ORCID: https://orcid.org/0000-0002-0619-5959)
- Dieter Saur (ORCID: https://orcid.org/0000-0001-5874-0210)
- Tatiana Borodianskiy-Shteinberg
- Shiran Didi Zurinam
- Elia Funaro Balouka
Institutions
- Bar-Ilan University (IL)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1477929
- Citations
- 5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.23