Rare co-occurrence of acquired epidermodysplasia verruciformis with eccrine porocarcinoma

Epidermodysplasia verruciformis (EV), linked to weakened immunity against specific human papillomavirus strains, poses a heightened risk of cutaneous dysplasia and malignancy. EV often leads to malignancies like squamous cell carcinoma. This case details a 25-year-old immunocompromised male presenting furfuraceous lesions and a peculiar scalp nodule. Following wide local excision and biopsies, eccrine porocarcinoma an uncommon malignancy associated with viral induction was diagnosed. Managing such cases poses significant challenges for surgeons and oncologists due to the rarity, morphological distinctiveness, and diagnostic ambiguities, which require adequate interprofessional team effort.