Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI
The microstructure of the cingulum bundle is related to brain cognitive functions. A probabilistic automatic approach is proposed to reconstruct the subdivisions of the cingulum bundle by diffusion-weighted images. The subdivisions showed different microstructural properties and variations in relation to the progression of dementia.
Authors
- Leonardo Brizi (ORCID: https://orcid.org/0000-0002-1250-6987)
- Danilo Greco (ORCID: https://orcid.org/0000-0002-0011-7001)
- Anastasiia Nagmutdinova (ORCID: https://orcid.org/0000-0002-6406-3268)
- James T. Grist (ORCID: https://orcid.org/0000-0001-7223-4031)
- Villiam Bortolotti (ORCID: https://orcid.org/0000-0002-9419-1965)
- Claudia M. Testa (ORCID: https://orcid.org/0000-0002-8591-9803)
- Carlo Golini (ORCID: https://orcid.org/0000-0002-1918-3703)
- Mattia Ricchi (ORCID: https://orcid.org/0009-0008-4430-3843)
- Guido Campani
Institutions
- University of Pisa (IT)
- University of Oxford (GB)
- Istituto Nazionale di Fisica Nucleare, Sezione di Bologna (IT)
- European Institute of Oncology (IT)
- University of Genoa (IT)
- University of Bologna (IT)
- Politecnico di Milano (IT)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s41747-025-00570-5
- Citations
- 6
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.16
Funders
- U.S. Department of Defense
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research