Aspirin Boosts Immune Response to Stop Cancer Spread

A new study in mice shows that COX-1 inhibitors, such as aspirin, block a platelet-mediated pathway that cancer cells use to evade immune detection and spread to other tissues. By reducing TXA2 production, aspirin enhances T-cell activity, leading to fewer metastases in the lungs and liver—a finding that could inform treatment.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-nw2025-0022
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Aspirin Boosts Immune Response to Stop Cancer Spread

Cancer Discovery
Immune cells in cancer
article

Aspirin Boosts Immune Response to Stop Cancer Spread

article en

Abstract

A new study in mice shows that COX-1 inhibitors, such as aspirin, block a platelet-mediated pathway that cancer cells use to evade immune detection and spread to other tissues. By reducing TXA2 production, aspirin enhances T-cell activity, leading to fewer metastases in the lungs and liver—a finding that could inform treatment.

Cancer Discovery
Openalex Percentile: Top 94%
Immune cells in cancer
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Aspirin Boosts Immune Response to Stop Cancer Spread · Cancer Discovery (2025) | TGRS Research Map | TGRS