SYL3C Aptamer-DNA Tetrahedra Conjugates Enable Near-Infrared Fluorescent Imaging of Colorectal Cancer
This study presents preliminary evidence for the SYL3C aptamer's potential in vivo imaging of EpCAM-positive CRC. The DTN conjugation strategy may extend the aptamer's metabolic stability and improve tumor uptake, expanding its applications in CRC diagnosis and treatment.
Authors
- Dawei Jiang (ORCID: https://orcid.org/0000-0002-4072-0075)
- Pinghui Li (ORCID: https://orcid.org/0000-0001-6456-3900)
- Xiaoyan Duan (ORCID: https://orcid.org/0009-0005-6715-2679)
- Jianbo Li (ORCID: https://orcid.org/0000-0003-0031-1645)
- Mengting Li (ORCID: https://orcid.org/0000-0002-2286-9001)
- Yiwen Li (ORCID: https://orcid.org/0009-0002-3898-6795)
- Zhidie Huang
Institutions
- Inner Mongolia University (CN)
- State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing (CN)
- Inner Mongolia People's Hospital (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Inner Mongolia Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/ijn.s510964
- Citations
- 3
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China