Cancer Cells Cooperate to Scavenge Extracellular Amino Acids

Main Finding: Tumor cells secrete an aminopeptidase that frees amino acids for uptake by neighboring cells, enhancing overall tumor fitness.Concept: Nutrient scavenging, driven by secreted CNDP2, is a mechanism of cell–cell cooperation that promotes tumor growth.Impact: This study highlights the role of CNDP2 in tumor cell cooperation in limiting environments as a potential cancer vulnerability.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-029
Primary Topic
Amino Acid Enzymes and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Cancer Cells Cooperate to Scavenge Extracellular Amino Acids

Cancer Discovery
Amino Acid Enzymes and Metabolism
article

Cancer Cells Cooperate to Scavenge Extracellular Amino Acids

article en

Abstract

Main Finding: Tumor cells secrete an aminopeptidase that frees amino acids for uptake by neighboring cells, enhancing overall tumor fitness.Concept: Nutrient scavenging, driven by secreted CNDP2, is a mechanism of cell–cell cooperation that promotes tumor growth.Impact: This study highlights the role of CNDP2 in tumor cell cooperation in limiting environments as a potential cancer vulnerability.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 95%
Amino Acid Enzymes and Metabolism
DOISourceOpenAlex
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Cancer Cells Cooperate to Scavenge Extracellular Amino Acids · Cancer Discovery (2025) | TGRS Research Map | TGRS