MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease

Altered body fat and muscle mass in Crohn's disease have been linked to adverse outcomes. Prediction of response to biologic therapy in small bowel CD (SBCD) would be useful for treatment optimisation. Body composition parameters measured using MRI cannot reliably predict biological therapeutic response or remission for SBCD.

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Publication Details

Journal
Insights into Imaging
Published
2025-03-19
DOI
https://doi.org/10.1186/s13244-025-01930-w
Citations
1
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
1.82

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MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease

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1 citations
Insights into Imaging
Inflammatory Bowel Disease
1.82
article

MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease

Lindsay Rogers, Eric Loveday, Alex Menys, Steve Halligan, Naomi Sakai, Stuart A. Taylor, Edmund Godfrey, Anisha Bhagwanani, Darren Boone, Nina Barratt, Maria Dilawershah, B Theis, Nora Thoua, Heather Fitzke, Felix Kpodo, Kamal Patel, Lana Ward, Ailsa L Hart, Maryam Mohsin, Klaartje Bel Kok, Andrew Plumb, Gauraang Bhatnagar, James Franklin, Sarah Langlands, Felicia Onoviran, Damian Tolan, Konstantina Rosiou, Roman Jastrub, Tracy Foster, Hannah Lambie, Elen Thomson, Anthony Higginson, Maira Hameed, Ilan Jacobs, Emma Helbren, Miles Parkes, Kashfia Chowdhury, Tariq Ahmad, Gordon W. Moran, Harbir Sidhu, Jaymin Patel, Norin Ahmed, Nik S. Ding, Sue Philpott, Nicola Gibbons, Simon P.L. Travis, Helen Rafferty, Sara McCartney, Saiam Ahmed, Safi Rahman, Nishant Patodi, Shankar Kumar, Biljana Brezina, Yakup Kilic, Peter D. Mooney, Stuart Bloom, Anmol Gangi, Elizabeth Isaac, Annamaria Wilce, Anvi Wadke, Amanda Cetroni, Suzanne Roffe, M. Joseph, Arun Gupta, Jaspreet Kaur, Rachel Baldwin‐Cleland, Charlotte Robinson, Steven R. Williams, Bessie Cipriano, Kamini Patel, Judith Holmes, Anisha Patel, Rachel Hyland, Richard Pollok, Teresita Beeston, Abi Seward, J Choudhury, Robert Przemiosolo, Javen Ramsami, Fardowsa Ahmed-Timms, Uday Bannur Chikkeragowda
article en
1 citations

Abstract

Altered body fat and muscle mass in Crohn's disease have been linked to adverse outcomes. Prediction of response to biologic therapy in small bowel CD (SBCD) would be useful for treatment optimisation. Body composition parameters measured using MRI cannot reliably predict biological therapeutic response or remission for SBCD.

Insights into ImagingVol. 16(1)
North Bristol NHS Trust (GB), Nottingham University Hospitals NHS Trust (GB), University College London Hospitals NHS Foundation Trust (GB), University of Nottingham (GB), University of Hull (GB), Barts Health NHS Trust (GB), Royal Devon & Exeter NHS Foundation Trust (GB), Western General Hospital (GB), Frenchay Hospital (GB), Wexham Park Hospital (GB), St George’s University Hospitals NHS Foundation Trust (GB), Frimley Park Hospital (GB), Royal London Hospital (GB), St James's University Hospital (GB), Royal Berkshire NHS Foundation Trust (GB), Epsom and St Helier University Hospitals NHS Trust (GB), Frimley Health NHS Foundation Trust (GB), University of Oxford (GB), St Vincent's Hospital Melbourne (AU), Portsmouth Hospitals NHS Trust (GB), St. Mark's Hospital (US), Homerton University Hospital NHS Foundation Trust (GB), Addenbrooke's Hospital (GB), St Mark's Hospital (GB), University College London (GB), Bournemouth University (GB)
Efficacy and Mechanism Evaluation Programme
Good health and well-being
Openalex Percentile: Top 17%
Inflammatory Bowel Disease
1.82
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