THE IMPACT OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY ON LIVER FUNCTION AND ENZYMATIC ANTIOXIDANTS IN PATIENTS FROM BASRAH PROVINCE

Glucose-6-phosphate dehydrogenase (G6PD) is an X-linked genetic disorder that represents the majority frequent enzymatic flaw worldwide, affecting approximately 400 million people, primarily of Asian, African and Middle Eastern descent. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that protects red blood cells and acts as an antioxidant. In other words, it protects red blood cells from oxidative damage in cases of stress in the event of a deficiency of the enzyme G6PD; this causes the breakdown of red blood cells before they mature, and this causes what is known as hemolysis, which in turn may cause hemolytic anemia. G6PD deficiency can result in hyperbilirubinemia, hemolysis and/or jaundice in neonates, but these symptoms are typically reversible with medical intervention. The objectives of this study were an attempt to evaluate and compare some enzymatic antioxidants and biochemical parameters of liver function in patients with G6PD enzyme deficiency. This study includes 58 subjects ages 1-15 years (30) patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) and (28) controls from healthy people who have normal activity of the G6PD enzyme. Samples were collected from Ibn Ghazwan Hospital in Basrah governorate from July to October 2023. The results of the study showed a significant increase in the concentration of serum AST, (P<0.01), ALT and ALP (P<0.05) in patients in G6PD deficient showed a significant increase in the concentration of serum AST (P<0.01), ALT and ALP (P<0.05) in patients in G6PD deficient group in comparison with the controls group was found a significant decrease in the activity of plasma (GPX, and SOD) in the patients' group in comparison with controls group(P<0.001 ). These results confirm that oxidative stress markers are potential new markers for the risk assessment of G6PD deficiency. The results indicated a nonsignificant positive correlation among G6PD (GPX and ALP). In contrast, a negative correlation was found among G6PD and (SOD, AST and ALT). Conclusion, Our findings are indicative of an association between abnormal G6PD levels and enzymatic antioxidants and liver functions. This indicates that the deficiency of G6PD may cause liver failure in the future.