Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE2 signaling pathway in mice
Celecoxib effectively inhibited lung-carcinoma development, inflammation, and emphysema, demonstrating the potential for chemoprevention in smokers and patients with COPD. Further studies on EP4 inhibitors for the prevention of emphysema and lung cancer are warranted.
Authors
- Naofumi Kameyama (ORCID: https://orcid.org/0000-0002-7920-3948)
- Tatsuro Naganuma (ORCID: https://orcid.org/0000-0002-8653-5553)
- Ahmed E. Hegab (ORCID: https://orcid.org/0000-0002-5432-7506)
- Hideki Terai (ORCID: https://orcid.org/0000-0002-1118-1930)
- Masayuki Shimoda (ORCID: https://orcid.org/0000-0003-4929-6546)
- H. Irie (ORCID: https://orcid.org/0000-0001-7973-1006)
- Jun Miyata (ORCID: https://orcid.org/0000-0002-3189-1702)
- Makoto Arita (ORCID: https://orcid.org/0000-0001-9902-0463)
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Shingo Nakayama (ORCID: https://orcid.org/0000-0003-1009-9860)
- Yae Kanai (ORCID: https://orcid.org/0000-0002-7904-9506)
- Hiroyuki Yasuda (ORCID: https://orcid.org/0000-0001-9966-8569)
- Junko Hamamoto (ORCID: https://orcid.org/0000-0002-8054-0124)
- Shotaro Chubachi (ORCID: https://orcid.org/0000-0002-5046-3762)
- Takashi Shimada (ORCID: https://orcid.org/0000-0003-3299-1630)
- Kaori Sakurai (ORCID: https://orcid.org/0000-0002-1565-781X)
- Akihiro Tsutsumi
- Shiro Otake
Institutions
- Jikei University School of Medicine (JP)
- Keio University (JP)
- Hokkaido University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- International University of Health and Welfare (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1557790
- Citations
- 4
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 5.58