Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two‐Sample, Two‐Step Mendelian Randomization Study
Our study supports using epigenetic age as a biomarker to predict stroke occurrence. Interventions specifically aimed at decelerating epigenetic aging, such as specific lifestyle changes, offer effective strategies for reducing stroke risk.
Authors
- Zifan Li (ORCID: https://orcid.org/0009-0006-8030-3352)
- Yuting Zeng (ORCID: https://orcid.org/0000-0001-8433-5235)
- Guozhi Huang (ORCID: https://orcid.org/0000-0002-5889-0603)
- Shuqi Zheng
- Jihua Zou
- Qi Zhang (ORCID: https://orcid.org/0000-0003-1121-8817)
- Yuxin Cai (ORCID: https://orcid.org/0009-0002-8452-4479)
- Baizhi Qiu (ORCID: https://orcid.org/0009-0002-9274-6776)
- Shuyang Wen
- Qing Zeng (ORCID: https://orcid.org/0000-0002-1206-7785)
- Zhishan Lin
- Yupeng Xiao
Institutions
- Hong Kong Polytechnic University (HK)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/brb3.70412
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province