Assessing Causality Between Plasma Brain‐Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study
This bidirectional MR analysis provides no evidence of a causal association between plasma BDNF levels and MDD. These findings prompt a re-evaluation of plasma BDNF as a biomarker for MDD and emphasize the need for further investigation into its functional role within the plasma as well as its levels and activity in the brain and cerebrospinal fluid.
Authors
- Cai‐Lan Hou (ORCID: https://orcid.org/0000-0002-7789-5602)
- Haozhang Huang (ORCID: https://orcid.org/0000-0001-7524-2854)
- Lin‐Tao Fu (ORCID: https://orcid.org/0000-0001-5167-5559)
- Ming Chen (ORCID: https://orcid.org/0000-0001-9869-4036)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4897-1012)
- Yihui Liu (ORCID: https://orcid.org/0000-0002-3716-125X)
Institutions
- Capital Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/brb3.70425
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00