Phage therapy analysis of effectiveness in comorbid patients with wounds and surgical infections of various etiology based on the results of a comparative clinical study

The principles of treatment of soft tissues and bones severe surgical infection in comorbid patients in our country are still based on the method of active surgical treatment of wounds developed in the Department of Wounds and Wound Infections of the Vishnevsky Institute of Surgery (now, the Vishnevsky National Research Medical Center of Surgery of the Ministry of Health of the Russian Federation). In relation to the first phase of wound healing, the results of treatment will largely depend on the radicality and thoroughness of the primary surgical debridement of the purulent focus, general and local treatment in the perioperative period. The increasing problem of resistance, the formation of biofilm forms of pathogens in chronic wounds, and comorbidity, which limits us to using a number of reserve antibiotics due to their toxicity, determine the importance of finding alternative treatment protocols for such complex clinical situations. The results of the study are encouraging and demonstrate that practical healthcare should continue to pay attention to the study and use of bacteriophage drugs in the complex treatment of surgical infection. It is necessary to look for new ways to deliver these drugs directly to the infection site in order to maintain their optimal concentration and activity.