MYLK-AS1 improves fracture by targeting miR-146a-5p to regulate cell viability and apoptosis in osteoblasts
MYLK-AS1 has potential as a diagnostic marker for DFH. By increasing the expression level of MYLK-AS1 in cells can reduce the level of miR-146a-5p, increase the activity of osteoblasts and reduce their apoptosis rate, thus affecting the process of fracture healing.
Authors
- Yingxuan Huang (ORCID: https://orcid.org/0009-0009-3761-9329)
- Haoze Gao
- Wuluhan Mahan
- Zhenyu Zhao (ORCID: https://orcid.org/0000-0003-1501-4272)
- Ning Liu (ORCID: https://orcid.org/0000-0002-7009-9187)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Xinjiang Medical University (CN)
- Harbin Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s13018-025-05688-1
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87