Distinct impact of RF and ACPA titre on the effectiveness and persistency of biologics and JAK inhibitors: The ANSWER cohort study
Considering effectiveness, aIL-6R showed the highest retention rates regardless of seropositivity. Although CTLA4-Ig and JAKis followed aIL-6R in RF or ACPA-positive cases, CTLA4-Ig showed the lowest retention rates in ACPA-negative cases.
Authors
- Kohei Tsujimoto (ORCID: https://orcid.org/0000-0001-6958-2983)
- Yuki Etani (ORCID: https://orcid.org/0000-0001-5741-5969)
- Takaaki Noguchi (ORCID: https://orcid.org/0000-0001-9938-6780)
- Hideki Amuro (ORCID: https://orcid.org/0000-0002-7299-2884)
- Shinya Hayashi (ORCID: https://orcid.org/0000-0003-4308-9845)
- Yuichi Maeda (ORCID: https://orcid.org/0000-0002-6831-8205)
- Atsushi Kumanogoh (ORCID: https://orcid.org/0000-0003-4749-7117)
- Ken Nakata (ORCID: https://orcid.org/0000-0002-8964-4229)
- Yasutaka Okita (ORCID: https://orcid.org/0000-0003-3620-8412)
- Kosuke Ebina (ORCID: https://orcid.org/0000-0002-2426-1024)
- Motomu Hashimoto (ORCID: https://orcid.org/0000-0002-9241-060X)
- Makoto Hirao (ORCID: https://orcid.org/0000-0002-1408-7851)
- Keisuke Nishimura (ORCID: https://orcid.org/0000-0002-5100-9166)
- T. Okano (ORCID: https://orcid.org/0000-0002-0873-5728)
- Tadashi Okano (ORCID: https://orcid.org/0000-0002-8849-9824)
- Seiji Okada (ORCID: https://orcid.org/0000-0002-5107-8209)
- Ayaka Yoshikawa (ORCID: https://orcid.org/0000-0002-1927-1295)
- Hideyuki Shiba (ORCID: https://orcid.org/0000-0002-9785-4533)
- Hideo Onizawa (ORCID: https://orcid.org/0009-0002-9372-726X)
- Akira Ōnishi (ORCID: https://orcid.org/0000-0002-3120-1273)
- Yonsu Son (ORCID: https://orcid.org/0000-0001-7244-7715)
- Ryota Hara (ORCID: https://orcid.org/0000-0001-8000-3196)
- Wataru Yamamoto (ORCID: https://orcid.org/0000-0002-0810-4221)
- Shotaro Tachibana (ORCID: https://orcid.org/0000-0001-7680-8071)
Institutions
- Kansai Medical University (JP)
- Osaka University of Health and Sport Sciences (JP)
- Kyoto University (JP)
- Kurashiki Central Hospital (JP)
- Osaka Minami Medical Center (JP)
- Health Information Management (BE)
- Osaka Metropolitan University (JP)
- Nara Medical University (JP)
- Kobe University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Modern Rheumatology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1093/mr/roaf029
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.67