Echinococcus granulosus sensu lato promotes osteoclast differentiation through DUSP4-MAPK signaling in osseous echinococcosis
This study reveals the molecular mechanism by which <i>Echinococcus granulosus</i> drives abnormal osteoclast activation through the DUSP4-MAPK signaling axis. Parasitic infection suppresses DUSP4 expression, relieving its negative regulation of the MAPK pathway and leading to excessive osteoclast differentiation. Restoring DUSP4 expression effectively reverses abnormal MAPK pathway activation, reducing osteoclast bone resorption activity to physiological levels. These findings not only provide new insights into the pathological mechanisms of bone destruction in osseous echinococcosis but also establish DUSP4 as a critical therapeutic target for pathological bone resorption, laying the groundwork for host-directed treatment strategies for parasitic bone diseases.
Authors
- Chenhui Shi
- Kai Xiong (ORCID: https://orcid.org/0000-0002-8170-0273)
- Zhendong Zhang (ORCID: https://orcid.org/0000-0001-6884-4179)
- Haohao Sun (ORCID: https://orcid.org/0009-0005-4675-0119)
- Jing Li (ORCID: https://orcid.org/0000-0001-9187-7809)
- Sibo Wang (ORCID: https://orcid.org/0000-0002-3204-2710)
- Yaqing Liu (ORCID: https://orcid.org/0000-0002-3161-676X)
- Qi Li (ORCID: https://orcid.org/0000-0002-7835-5886)
- Yiping Huang (ORCID: https://orcid.org/0000-0003-2353-5561)
- Yi Dai
- Weishan Wang (ORCID: https://orcid.org/0000-0001-7827-2696)
Institutions
- Shihezi University (CN)
- Xi'an Honghui Hospital (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fmicb.2025.1558603
- Citations
- 1
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Shihezi University