Aging-related impairment of neurogenic chloride secretion in human colon mucosa
Significant impairments in neurogenic Cl<sup>-</sup> secretion occur in the aged colon, correlating with the degeneration of cholinergic and VIPergic nerves in the mucosa. This study could enhance our understanding of the pathophysiology of elderly constipation.
Authors
- Ruiyun Wang (ORCID: https://orcid.org/0000-0002-8813-3064)
- Jun Song (ORCID: https://orcid.org/0000-0001-9970-8313)
- Jing He
- Lei Zhang (ORCID: https://orcid.org/0000-0001-7769-7377)
- Tao Bai (ORCID: https://orcid.org/0000-0002-4268-4194)
- Pengcheng Yang (ORCID: https://orcid.org/0000-0002-7359-9195)
- Xiaohua Hou (ORCID: https://orcid.org/0000-0002-4777-7920)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fphys.2025.1540465
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China