Expression profiles of CYP1A1 and CYP1B1 enzymes in Non-small Cell Lung Cancer of Turkish Patients

Background . The cytochrome P450 enzymes CYP1A1 and CYP1B1 are involved in the metabolism of carcinogens and have been linked to various cancers, including lung cancer, primarily through their overexpression in tumor tissues. Aim of study . This study describes the CYP1A1 and CYP1B1 expression profiles in lung adenocarcinoma (AC) and lung squamous cell carcinoma (SCC), and explores the possible associations with demographic and clinical features among Turkish patients. Material and methods . This retrospective study analyzed clinical data from 40 patients with lung adenocarcinoma and lung squamous cell carcinoma. tumor and adjacent healthy tissue samples were immunohistochemically stained to profile CYP1A1 and CYP1B1 expression. Associations between protein expression levels and patient characteristics were examined. Results . Significant immunohistochemical differences were found between tumorous and healthy tissues for CYP1A1 and CYP1B1. Conclusion . The study suggests that the CYP1A1 and CYP1B1 expression profiles in lung adenocarcinoma and lung squamous cell carcinoma among Turkish patients may have biomarker value for risk stratification and early detection.