Zn/H<sub>2</sub>O-mediated tandem reductive cyclization of 2-(2-nitrophenyl)-1<i>H</i>-benzo[<i>d</i>]imidazoles with aldehydes to synthesize 5,6-dihydrobenzo[4,5]imidazo[1,2-<i>c</i>]quinazolines
A one-pot tandem approach to synthesize 5,6-dihydrobenzo[4,5]imidazo[1,2-<i>c</i>]quinolones has been developed from 2-(2-nitrophenyl)-1<i>H</i>-benzo[<i>d</i>]imidazoles and aldehydes <i>via</i> a Zn/H<sub>2</sub>O-mediated reductive cyclization process, characterised by cheap and readily available raw materials, a simple, green, economical and efficient protocol, good product yields and product diversity.
Authors
- Guisheng Zhang (ORCID: https://orcid.org/0000-0001-9880-950X)
- Zhenhua Guo (ORCID: https://orcid.org/0000-0002-8201-0864)
- Xiaopeng Zhang (ORCID: https://orcid.org/0000-0002-4647-7002)
- Zihua Yang (ORCID: https://orcid.org/0000-0003-1725-9820)
- Qiuyang Pang
Institutions
- Henan Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4ob01976h
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00