Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by N-hetarenes: a new class of therapeutic candidates for Alzheimer’s disease

We demonstrated that 4-(6-(arylpyrimidin-4-yl)piperazine-1-carboximidamides) are a promising class of <i>N</i>-hetarenes for developing next-generation anti-AD drugs. The reported class of compounds inhibited MARK4 activity in-vitro at micromolar concentration by targeting the ATP-binding pocket. These findings provide valuable insights for future drug design.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-03-19
DOI
https://doi.org/10.3389/fmed.2025.1529845
Citations
1
Primary Topic
Computational Drug Discovery Methods
Type
article
Field-Weighted Citation Impact
1.50
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article

Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by N-hetarenes: a new class of therapeutic candidates for Alzheimer’s disease

Ashanul Haque, Khalaf M. Alenezi, Shahzaib Ahamad, Dinesh Gupta et al.
1 citations
Frontiers in Medicine
Computational Drug Discovery Methods
1.50
article

Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by N-hetarenes: a new class of therapeutic candidates for Alzheimer’s disease

Ashanul Haque, Khalaf M. Alenezi, Shahzaib Ahamad, Dinesh Gupta, Md. Ataur Rahman, Saleha Anwar, Mohd. Saeed Maulana Abdul Rasheed
article en
1 citations

Abstract

We demonstrated that 4-(6-(arylpyrimidin-4-yl)piperazine-1-carboximidamides) are a promising class of <i>N</i>-hetarenes for developing next-generation anti-AD drugs. The reported class of compounds inhibited MARK4 activity in-vitro at micromolar concentration by targeting the ATP-binding pocket. These findings provide valuable insights for future drug design.

Frontiers in MedicineVol. 12
New York University Abu Dhabi (AE), University of Ha'il (SA), International Centre for Genetic Engineering and Biotechnology (IN), Jamia Millia Islamia (IN)
Good health and well-being
Openalex Percentile: Top 19%
Computational Drug Discovery Methods
1.50
DOIOpen Access PDFOpenAlex
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Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by N-hetarenes: a new class of therapeutic candidates for Alzheimer’s disease — Ashanul Haque, Khalaf M. Alenezi, et al. · Frontiers in Medicine (2025) | TGRS Research Map | TGRS