Arginase-II promotes melanoma and lung cancer cell growth by regulating Sirt3-mtROS axis
Altogether, our findings demonstrate a critical role of Arg-II-Sirt3-mtROS cascade in promoting melanoma growth, migration, nuclear deformation, and DNA damage linking to melanoma progression and malignancy, which could be therapeutic targets for cancers such as melanoma and lung carcinoma.
Authors
- Duilio Michele Potenza (ORCID: https://orcid.org/0000-0003-2442-9154)
- Andrea Brenna (ORCID: https://orcid.org/0000-0002-8542-9855)
- Xin Cheng (ORCID: https://orcid.org/0000-0002-3817-3084)
- Xiu‐Fen Ming (ORCID: https://orcid.org/0000-0002-5848-4496)
- Zhihong Yang (ORCID: https://orcid.org/0000-0002-4133-5099)
- Yang Yang (ORCID: https://orcid.org/0000-0001-8147-7932)
- Santhoshkumar Sundaramoorthy
Institutions
- University of Fribourg (CH)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fcell.2025.1528972
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94