Teriparatide mitigates oxidative stress following spinal cord injury and enhances neurological recovery via the Nrf2/HO-1 signaling pathway
Our findings demonstrate that teriparatide activates the Nrf2/HO-1 antioxidant pathway, effectively mitigating oxidative damage in SCI. This repositioning of an FDA-approved osteoporosis drug presents a clinically translatable strategy for neuroprotection.
Authors
- Qiang Xiao (ORCID: https://orcid.org/0000-0002-3018-1784)
- Liang Deng (ORCID: https://orcid.org/0000-0002-0964-9426)
- Yun Feng (ORCID: https://orcid.org/0000-0001-8198-5240)
- Guo Jia
- Xiong Moliang
- Ai Gangtong
- Luo Caiguang
Institutions
- Shangrao Normal University (CN)
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fphar.2025.1538857
- Citations
- 2
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94