A modeling perspective on fluid flow behavior in the human gut under impact of electrokinetics

This study examines how electro kinetics and peristaltic motion affect intestinal fluid flow in bio-microfluidic devices and electrokinetic separation methods. The Oldroyd-B fluid is ideal for modeling complicated gastrointestinal fluids like chyme and mucus because to their viscoelasticity. Including electroosmotic effects allows realistic gut wall nutrient transport and absorption models. Debye-Huckel approximations, low Reynolds number assumptions for the gut channel, and continuity, Poisson, and momentum equations provide the mathematical framework. Analytical solutions are developed using perturbation methods to examine Reynolds number, dimensionless wave number, relaxation and retardation time parameters, electroosmotic parameter, and Heltmholtz-Smoluchowski velocity. Graphic study shows that electroosmotic parameter and Heltmholtz-Smoluchowski velocity increase axial velocity near channel walls. Peristaltic flow alone does not increase pressure gradient as much as electroosmotic actions do. As electroosmotic parameter rises, bolus size and streamlines decrease. This paper provides a solid mathematical framework for understanding intestinal fluid dynamics and provides biological insights. Validating and improving the model with particular examples and current research, this work seeks to improve gastrointestinal illness knowledge and medicine delivery system design by revealing gastrointestinal fluid dynamics.