Neutrophil extracellular traps are associated with poor response to neoadjuvant therapy and poor survival in pediatric osteosarcoma
These data highlight the potential role of NETs in OS's TME biology, and suggest that NETs released by tumor infiltrating neutrophils can serve as an independent prognostic factor for poor response to neoadjuvant therapy and overall survival in patients with OS. Such insights may inform the development of tailored treatment approaches in OS.
Authors
- Claudia Rössig (ORCID: https://orcid.org/0000-0002-8672-5285)
- Ronny Maman
- Michal Manisterski
- Yoav Binenbaum (ORCID: https://orcid.org/0000-0001-9901-7782)
- Anna Shusterman
- Szilvia Baron (ORCID: https://orcid.org/0000-0002-0406-1359)
- Ronit Elhasid (ORCID: https://orcid.org/0000-0002-5663-6919)
- Victoria Fidel (ORCID: https://orcid.org/0000-0003-2695-1819)
- Dmitry Vaisman
- Rachel Shukrun (ORCID: https://orcid.org/0000-0003-0140-9601)
- Osnat Sher (ORCID: https://orcid.org/0000-0003-0280-8102)
Institutions
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- University Hospital Münster (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.3389/fonc.2025.1472716
- Citations
- 5
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.99