Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study
In HCC patients with MVI, adjuvant TACE combined with targeted therapy or targeted immunotherapy significantly enhances DFS, though no OS benefit was observed. The developed nomogram provides a reliable tool for risk stratification and personalized postoperative management in this high-risk patient population.
Authors
- Haifeng Xu (ORCID: https://orcid.org/0000-0002-6976-1129)
- Dandan Hu (ORCID: https://orcid.org/0000-0001-7905-8536)
- Xueshuai Wan (ORCID: https://orcid.org/0000-0003-2140-5384)
- Peng Wei (ORCID: https://orcid.org/0000-0001-7758-6116)
- Yongchang Zheng (ORCID: https://orcid.org/0000-0002-5916-2392)
- Xiangan Wu
- Yaojun Zhang (ORCID: https://orcid.org/0000-0002-9752-4729)
- Xiaokun Chen (ORCID: https://orcid.org/0000-0001-5784-7411)
- Huay Cheem Tan (ORCID: https://orcid.org/0000-0001-7372-4702)
- Xiao Liu (ORCID: https://orcid.org/0000-0001-5173-6075)
- Liguo Liu (ORCID: https://orcid.org/0000-0002-6064-8701)
- Shunda Du (ORCID: https://orcid.org/0000-0002-9357-3259)
- Mei Guan (ORCID: https://orcid.org/0000-0001-5929-7142)
- Xinting Sang (ORCID: https://orcid.org/0000-0003-1952-0527)
- Jie Pan (ORCID: https://orcid.org/0000-0002-4993-298X)
- Haitao Zhao (ORCID: https://orcid.org/0000-0002-3444-8044)
- Yilei Mao (ORCID: https://orcid.org/0000-0003-0449-4223)
- Xin Lü (ORCID: https://orcid.org/0009-0000-8074-4592)
- Xiaoyan Chang (ORCID: https://orcid.org/0000-0003-0963-642X)
- Kang Zhou (ORCID: https://orcid.org/0000-0003-4681-2795)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jhc.s504016
- Citations
- 5
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College