Synthesis and Evaluation of Optical Properties, SHP2 Inhibitory Activity, and Cellular Imaging for Novel 2-Quinolone Derivatives
Therefore, we hope that compound 8A could act as a lead to develop novel, convenient, and bifunctional chemical tools to explore the mechanism of drug-target interactions in intact tissue and promote the integrated research progress of diagnosis and treatment of SHP2 related diseases.
Authors
- Xin Wang (ORCID: https://orcid.org/0000-0003-2968-2634)
- Yubo Zhou (ORCID: https://orcid.org/0000-0002-0694-3697)
- Wenlong Wang (ORCID: https://orcid.org/0000-0002-0324-3003)
- Yuting Yang (ORCID: https://orcid.org/0000-0001-6859-6195)
- Lixin Gao (ORCID: https://orcid.org/0000-0002-6691-7992)
- Jia Li (ORCID: https://orcid.org/0000-0003-3224-001X)
- Chun Zhang
- Suya Gan
Institutions
- Jiangnan University (CN)
- Henan University (CN)
- Shanghai Institute of Materia Medica (CN)
- National Center for Drug Screening (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-03-19
- DOI
- https://doi.org/10.2174/0118715206337347250219112715
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00