PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate–Induced Colitis and Modulate Gut Microbiota
Our findings reveal that activation of PPARγ and PPARβ/δ can balance the gut microbiota in mice and ameliorate experimental colitis in mice. Thus, PPARγ and PPARβ/δ have protective effects against IBD and could serve as novel therapeutic targets for its treatment.
Authors
- Haoming Xu (ORCID: https://orcid.org/0000-0002-8131-7477)
- Jinxia Hu (ORCID: https://orcid.org/0009-0009-4906-8114)
- Youlian Zhou (ORCID: https://orcid.org/0000-0002-7107-3288)
- Yuqiang Nie (ORCID: https://orcid.org/0000-0001-7037-5340)
- Chen Huang (ORCID: https://orcid.org/0000-0001-8631-3654)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-1214-7849)
- Jianhong Li (ORCID: https://orcid.org/0000-0003-4354-9231)
- Jianlin Xu (ORCID: https://orcid.org/0000-0002-4380-9067)
- Jing Xu (ORCID: https://orcid.org/0000-0002-3946-2056)
- Xue Guo (ORCID: https://orcid.org/0000-0003-3533-023X)
Institutions
- Guangzhou First People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1111/jgh.16929
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province