QSAR and Molecular Docking Studies on Uracil-based Benzoic Acid and Ester Derivatives to Explore Novel Dipeptidyl Peptidase-4 Inhibitors
From the results, four new congeners have been predicted and validated with good inhibitory activity against DPP-4. Present work reflects that with further optimization of these scaffolds, more selective, potent, and bioavailable DPP-4 inhibitors can be developed for the treatment of T2DM.
Authors
- Pradeep Pilania (ORCID: https://orcid.org/0000-0001-5434-1474)
- Prithvi Pal Singh (ORCID: https://orcid.org/0009-0003-8584-2687)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-03-19
- DOI
- https://doi.org/10.2174/0113816128331664250206113701
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05