Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy
Higher s-NfL was associated with nerve fiber dysfunction and loss quantified by QST and IENFD, but not with pain or clinical DPN scales. S-NfL may reflect the severity of nerve fiber damage underlying DPN.
Authors
- David Bennett (ORCID: https://orcid.org/0000-0002-7996-2696)
- Jishi John
- Laura L. Määttä (ORCID: https://orcid.org/0000-0003-2960-3158)
- Mathilde M.V. Pascal (ORCID: https://orcid.org/0000-0002-2841-6943)
- Solomon Tesfaye (ORCID: https://orcid.org/0000-0003-1190-1472)
- Daniel R. Witte (ORCID: https://orcid.org/0000-0002-0769-2922)
- Claus Vinter Bødker Hviid (ORCID: https://orcid.org/0000-0003-1740-7555)
- Tina Parkner (ORCID: https://orcid.org/0009-0007-2351-7431)
- Georgios Baskozos (ORCID: https://orcid.org/0000-0001-9237-5878)
- Eleanor Ferris (ORCID: https://orcid.org/0000-0002-6931-1398)
- Andreas C. Themistocleous (ORCID: https://orcid.org/0000-0002-1089-1543)
- Pallai Shillo (ORCID: https://orcid.org/0000-0002-4576-3365)
- Troels S. Jensen (ORCID: https://orcid.org/0000-0002-3487-6380)
- Juan D. Ramirez (ORCID: https://orcid.org/0000-0003-4303-684X)
- Signe T. Andersen (ORCID: https://orcid.org/0000-0001-5183-3502)
- Andrew S.C. Rice (ORCID: https://orcid.org/0000-0001-9533-5636)
- Helen Laycock (ORCID: https://orcid.org/0000-0003-2903-0038)
Institutions
- Aarhus University (DK)
- Royal Hallamshire Hospital (GB)
- Aarhus University Hospital (DK)
- John Radcliffe Hospital (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Danish Pain Research Center (DK)
- Imperial College London (GB)
Publication Details
- Journal
- Diabetes Research and Clinical Practice
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.diabres.2025.112098
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Abbott Laboratories
- Pfizer
- AstraZeneca
- Sanofi
- Procter and Gamble
- Biogen
- Harvard University
- Aarhus Universitet
- Aarhus Universitetshospital
- Wellcome Trust
- UK Research and Innovation
- Nevro
- Imperial College London
- European Commission
- European Foundation for the Study of Diabetes
- Novo Nordisk
- Astellas Pharma
- Novo Nordisk Fonden
- Versus Arthritis
- Mitsubishi Tanabe Pharma Corporation
- Diabetesforeningen
- TrigoCare International
- Wörwag Pharma
- Medical Research Council
- Biotechnology and Biological Sciences Research Council