Genome Mining and Targeted Discovery of Twistane-Containing Angucyclinones from Marine <i>Streptomyces phaeochromogenes</i> XSA2
Genome mining of a type II PKS biosynthetic gene cluster from marine <i>Streptomyces phaeochromogenes</i> XSA2 resulted in the discovery of 12 angucyclinone derivatives, including nine new phaeomycins A-I (<b>1</b>-<b>9</b>) and three known analogs (<b>10</b>-<b>12</b>). Phaeomycin A (<b>1</b>) contains a unique phthalide moiety connected to a rare twistane skeleton that has not been previously identified in natural products. The chemical structures of the isolated compounds were established via extensive spectroscopic and X-ray crystal-lographic analyses. A plausible biosynthetic pathway for <b>1</b>-<b>2</b> was proposed based on bioinformatic analysis.
Authors
- You‐Ming Zhang (ORCID: https://orcid.org/0000-0001-5722-1347)
- Liu Yang (ORCID: https://orcid.org/0000-0002-4179-8587)
- Haiyan Sui
- Xiaoying Bian (ORCID: https://orcid.org/0000-0002-1356-3211)
- Haibo Zhou (ORCID: https://orcid.org/0000-0001-9656-6479)
- Xiangmei Ren
- Zong-Jie Wang (ORCID: https://orcid.org/0000-0001-6221-8433)
- Qingsheng Yang (ORCID: https://orcid.org/0000-0002-1621-0497)
- Li Feng (ORCID: https://orcid.org/0000-0002-8692-7645)
- Xingxing Shi
- Xiaoju Li (ORCID: https://orcid.org/0000-0003-1359-156X)
- Ping Yan (ORCID: https://orcid.org/0000-0001-7523-9460)
- Xingkun Hao
Institutions
- Shandong University (CN)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c00514
- Citations
- 4
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China