Comparative analysis of Invasive Pneumococcal Disease (IPD) trends in the US

This study investigates the trends of Invasive Pneumococcal Disease (IPD) in the US from 1998 to 2021, segmented by age groups, using data from the CDC. The trends were visualized using generative AI, revealing a correlation between the IPD trends in the US and the COVID-19 pandemic. A significant reduction in the number of cases for serotype 14 was observed in the "< 2" age group, which decreased from 246 cases in 2000–58 cases in 2001. This drop could be a contributing factor to the overall decline in cases during this period. Similarly, in the "65 + " age group, a significant reduction in the number of cases for serotype 3 was noticed, which fell from 197 cases in 2019–64 cases in 2021. These findings underscore the importance of continuous monitoring and intervention strategies in managing IPD. • IPD trends inform disease prevalence, antibiotic resistance, and outbreaks. • Significant decrease in IPD cases (1998–2021) by older age groups due to serotype 3. • Significant decrease in IPD cases (1999–2002) by < 2 age group due to serotype 14. • Higher IPD rates in older age groups; younger groups had no COVID-19 effect.