Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning
Three of five identified enterotypes were inversely associated with OA status and levels of OA associated cytokines. These exploratory analyses revealed associations between the gut microbiome, cytokines, and OA outcomes, suggesting potentially cytokine-mediated mechanisms of the effects of gut composition on OA in obese individuals, and providing a basis for further investigation of the underlying causal mechanisms.
Authors
- B. Duncan X. Lascelles (ORCID: https://orcid.org/0000-0002-2950-9009)
- Richard F. Loeser (ORCID: https://orcid.org/0000-0003-2832-6144)
- M. Andrea Azcárate-Peril (ORCID: https://orcid.org/0000-0003-0325-1289)
- Liubov S Arbeeva (ORCID: https://orcid.org/0000-0001-5004-419X)
- Amanda E. Nelson (ORCID: https://orcid.org/0000-0002-9344-7877)
- Delisha A. Stewart (ORCID: https://orcid.org/0000-0001-7516-2790)
- Cameron E. Kurz
Institutions
- University of North Carolina at Chapel Hill (US)
- Howard University (US)
- North Carolina State University (US)
- David H. Murdock Research Institute (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100603
- Citations
- 5
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Arthritis Foundation
- University of North Carolina
- National Institutes of Health
- Centers for Disease Control and Prevention
- Office of the Director
- NIH Office of the Director
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Advancing Translational Sciences